Open Access Open Access  Restricted Access Subscription or Fee Access

Clinical Significance of HbA1c in the Management of Complicated Type 2 Diabetic Patients in Bangladesh

Priyanka Roy

Abstract


Diabetic patients are generally suffered by several other diseases such as dyslipidemia, cardiovascular and urinary diseases. Glycated hemoglobin (HbA1c) is a commonly used marker for identifying long-term glycemic control.  The objective of this study is to investigate the co-relation of HbA1c with blood glucose level, serum lipid, cholesterol and creatinine level in type 2 diabetes patients.  A prospective study was carried to collect data from the diabetic hospital, Dhaka, Bangladesh though interview and from the current pathological reports of the patients and then data was analyzed using Excel. Results showed that serum lipid concentration, fasting and postprandial blood glucose are directly related with the percentage of HbA1c in the blood. In addition, risks of hypertension, dyslipidemia and kidney diseases also showed higher in high percentage of HbA1c in the blood of the patients. However, HbA1c is independent with age, weight and height of the patients. This study will help to mange complicated diabetic patients by controlling HbA1c from the beginning of the treatment.

 

Handle: http://hdl.handle.net/20.500.11903/mjmbr.v2n2.9

 


Keywords


HbA1c, complicated diabetes, type 2 diabetes

Full Text:

PDF

References


American Diabetes Association. Executive summary: standards of medical care in diabetes – 2010. Diabetes Care 2010; 33(Suppl.1):S4–10.

Chan WB, Tong PC, Chow CC, So WY, Ng MC, Ma RC, Osaki R, Cockram CS, Chan JC (2005) Triglyceride predicts cardiovascular mortality and its relationship with glycemia and obesity in Chinese type 2 diabetic patients. Diabetes Metab Res Rev 21:183–188.

Christensen DL, Witte DR, Kaduka L et al. Moving to an A1C-based diagnosis of diabetes has a different impact on prevalence in different ethnic groups. Diabetes Care 2010; 33: 580–582.

Dagogo-Jack S. Pitfalls in the use of HbA(c) as a diagnostic test: the ethnic conundrum. NatRevEndocrinol 2010; 6:589–93.

Davey RA, Tabbutt NC, Favaloro JM, O’Neal DN, Rae D, Zajac JD, Best JD (2006) Severe combined hyperlipidemia and retinal lipid infiltration in a patient with type 2 diabetes mellitus. Lipids Health Dis 5:29–33.

Esteghamati A, Abbasi M, Nakhjavani M, Yousefizadeh A, Basa AP, Afshar H (2006) Prevalence of diabetes and other cardiovascular risk factors in an Iranian population with acute coronary syndrome. Cardiovasc Diabetol 5:15.

Faulkner MS, Chao WH, Kamth SK, Quinn L, Fritschi C, Maggiore JA, Williams RH, Reynolds RD (2006) Total homocysteine, diet and lipid profiles in type 1 and type 2 diabetic and nondiabetic adolescents. J Cardiovasc Nurs 21:47–55.

Giansanti R, Rabini RA, Romagnoli F, Fumelli D, Sorichetti P, Boemi M, Fumelli P (1999) Coronary heart disease, type 2 diabetes mellitus and cardiovascular disease risk factors: a study on a middle-aged and elderly population. Arch Genontol Geriatr 29:175–182.

Gotto AM Jr (2007) Cardiologist’s role in improving glucose control and global cardiovascular risk in patients with type 2 diabetes mellitus. Am J Cardiol 99:3–5.

International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes.DiabetesCare2009; 32: 1327–34.

Ito C, Maeda R, Ishida S, Sasaki H, Harada H (2000) Correlation among fasting plasma glucose, two-hour plasma glucose levels in OGTT and HbA1c. Diabetes Res Clin Pract 50:225–230.

Jones PH (2006) Clinical significance of recent lipid trials on reducing risk in patients with type 2 diabetes mellitus. Am J Cardiol 99:133–140.

Ko GT, Chan JC, Woo J, Lau E, Yeung VT, Chow CC, Li JK, So WY, Chan WB, Cockram CS (1998) Glycated hemoglobin and cardiovascular risk factors in Chinese subjects with normal glucose tolerance. Diabet Med 15:573–578.

Miljanovic B, Glynn RJ, Nathan DM, Manson JE, Schaumberg DA (2004) A prospective study of serum lipids and risk of diabetic macular edema in type 1 diabetes. Diabetes 53:2883–2892.

Nasri H, Yazdani M (2006) The relationship between serum LDL-cholesterol, HDL-cholesterol and systolic blood pressure in patients with type 2 diabetes. Kardiol Pol 64:1364–1368.

Rader DJ (2007) Effect of insulin resistance, dyslipidemia, and intra-abdominal adiposity on the development of cardiovascular disease and diabetes mellitus. Am J Med 120:S12–S18.

Rosediani M, Azidah AK, Mafauzy M (2006) Correlation between fasting plasma glucose, post prandial glucose and glycated haemoglobin and fructosamine. Med J Malaysia 61:67–71.

Simon D, Coignet MC, Thibult N, Senan C, Eschwege E. Comparison of glycosylated hemoglobin and fasting plasma glucose with two-hour post-load plasma glucose in the detection of diabetesmellitus. AmJEpidemiol1985;122:589–93.

Smith SC Jr (2007) Multiple risk factors for cardiovascular disease and diabetes mellitus. Am J Med 120:S3–S11

World Health Organisation. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO â„ IDF Consultation. Geneva: World Health Organisation, 2006.

World Health Organisation. Use of Glycated Haemoglobin (HbA1c) in the Diagnosis of Diabetes Mellitus. Geneva: World Health Organisation, 2011.

-- 0 --


Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 Priyanka Roy

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.