Assessment of Multidrug Resistance Tuberclosis Treatment Outcome in St. Petre’s Tuberclosis Specialized Hospital, Addis Ababa, Ethiopia

Authors

  • Tsegaye Tulu Addis Ababa University
  • Mesfin Haile Kahissay Addis Ababa University

DOI:

https://doi.org/10.18034/mjmbr.v2i1.381

Keywords:

St. Petre’s Tuberclosis Specialized Hospital, Ethiopia, Multidrug Resistance, Tuberclosis Treatment

Abstract

The purpose of this study is to assess the treatment outcome of MDR-TB among patients who are treated in St. Peter’s TB Specialized Hospital from January 1, 2009 to December 31, 2010. A periodic retrospective cross sectional study was conducted on MDR-TB patient who were followed up to check their treatment out come. The study was utilized quantitative method for data collection by using patient registration book from MDR-TB clinic retrospectively. Using data collecting format, cure rate, failure rate, death rate, card number, sex, address, and co-morbid illness was be collected. The association with the patient treatment outcome was assessed using SPSS version 15 for window using chi-square and odds ratio and Epi info for data entry. In this study the treatment outcome was measured by cure rate, death rate, failure rate and default rate. Base on this study that was done in St. Peter’s TB specialized hospital from January 1, 2009 to December 31, 2010 cohort study, out of 166 MDR-TB patients, the treatment completion and cure rate was 7(4.2%). Regarding to sex more female 6(7.1%) of the treated patients were cured than male 1(1.23%) from the total females and males patients respectively. While 143(83.5%) were still on treatment, 1(0.6%) patient was defaulted from treatment for more than two months and the outcome was not traced. Treatment failure was not reported in this study. This finding indicates that from the study population, no treatment failure and one treatment interruption (default) was observed. In conclusion patients in this cross sectional study were found in good follow up and DOTS program. On the other hand the cure rate 7(4.2%) of this study showed that encouraging treatment outcome was obtained from the MDR-TB treatment plan. The result that was obtained from this study showed that the majority of MDR-TB patients in this retrospective study were found still on treatment.

 

Downloads

Download data is not yet available.

Author Biographies

  • Tsegaye Tulu, Addis Ababa University

    Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, ETHIOPIA

  • Mesfin Haile Kahissay, Addis Ababa University

    Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, ETHIOPIA

References

Asebe G, Ameni G and Tafess K. 2014. Ten years tuberculosis trend in Gambella Regional Hospital, South Western Ethiopia. Malaysian Journal of Medical and Biological Research, 1, 18-24.

Bendayan D, Hendler A, Polansky V (2011). Outcome of hospitalized MDR-TB patients: Israel 2000-2005. Eur J Clin Microbiol Infect Dis. Mar, 30(3):375-9. Epub, 2010 Oct 23.

Carpels G, Fissette K., Limbana V, Van Deun A (1995). Drug resistant tuberculosis in sub-Saharan Africa an estimation of incidence and cost for the year 2000.Tubercle and Lung Disease, 76, 480-86). DOI: https://doi.org/10.1016/0962-8479(95)90522-7

Centers for Disease Control (1990). Outbreak of multidrug-resistant tuberculosis-Texas, California, and Pennsylvania. MMWR Morb Mortal Wkly Rep, 39 (22): 369-72).

Centers for Disease Control (1991). Nosocomial transmission of multidrug-resistant tuberculosis among HIV-infected persons-Florida and New York, 1988–1991. MMWR Morb Mortal Wkly Rep 40: 585–591.

Centers for Disease Control (1991). Transmission of multidrug-resistant tuberculosis from an HIV-positive client in a residential substance-abuse treatment facility-Michigan. MMWR Morb Mortal Wkly Rep, 40: 129–131.

Centers for Disease Control Prevention (2006). Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000-2004. Morb. Mortal. Wkly Rep. 55, 301-305.

Chan E D and Iseman M D (2002). Current medical treatment for tuberculosis; Br. Med. J. 325 1282–1286.

Chiang C-Y,Eur respire J (2006); 28:980-985. DOI: https://doi.org/10.1183/09031936.06.00125705

Datta M, Radhamani M P, Selvaraj R, Paramasivan C N, Gopalan B N, Sudeendra C R and prabhakar R (1993). Critical assessment of smear-positive pulmonary tuberculosis patients after chemotherapy under the district tuberculosis programme; Tuber. Lung Dis. 74 180–186. DOI: https://doi.org/10.1016/0962-8479(93)90008-L

De Cock KM, Soro B, Coulibaly IM, Lucas SB (1992). Tuberculosis and HIV infection in sub-Saharan Africa. JAMA 1992; 268: 1581–87. 37

Dhingra V. K, Rajpal S, Anshu Mittal and Hanif M. (2008). Outcome of MDR-TB cases treated by individualized regimens at a tertiary level clinic. Indian J Tuberc, 55:15-21.

Drobniewski F A and Balabanova Y M (2002). The diagnosis and management of multiple-drug- resistant tuberculosis at the beginning of the new millennium; Int. J. Infect. Dis. 6 S21–S31.

Edlin BR, Tokars JI, Grieco (1992). An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome. N Engl J Med 326 (23): 1514–1521.

Espinal MA, Kim SJ, Surarez PG (2000).Standard short-course chemotherapy for drug-resistant tuberculosis treatment outcome in 6 countries. JAMA, 283:2537–45.

Federal ministry of health (2008). Tuberculosis, leprosy and TB/HIV prevention and control programme manual, 4-5.

Federal Ministry of Health (2009). Guidelines for program and clinical management of Drug resistance Tuberculosis. Ethiopia, 3-4.

Ferrer G, Acuna-Villaorduna C, Escobedo M(2010). Outcomes of multidrug-resistant tuberculosis among binational cases in El Paso, Texas. Am J Trop Med Hyg; 83(5):1056-8.

Fischl MA, Uttamchandani RB, Daikos GL (1992). An outbreak of tuberculosis caused by multiple-drug resistant tubercle bacilli among patients with HIV infection. Ann Intern Med, 117: 177–183.

Gandhi, N.R., Moll, A., Sturm, A.W., Pawinski, R., Govender, T., Lalloo, U., Zeller, K., Andrews, J., Friedland, G (2006). Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368, 1575—1580. DOI: https://doi.org/10.1016/S0140-6736(06)69573-1

Ghafoor A and Khan AA. 2014. Emperical Study about Fears and Misconceptions of Aids and Hepatitis among Medical Students. Malaysian Journal of Medical and Biological Research, 1, 25-34.

Glynn, J. R., Warndorff, D. K., Fine, P. E., Munthali, M. M., Sichone, W. & Ponninghaus, J. M. (1998). Measurement and determinants of tuberculosis outcome in Karonga District, Malawi. Bulletin of the World Health Organization, 76, 295-305.

Goble M, Iseman M D, Madsen L A (1993). Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampicin; N. Engl. J. Med. 328 527–532.

Hadhrami SA, Saaban AB, Ibrahim AB, Shahzad M and Ahmad I. 2014. Linear Active Control Algorithm to Synchronize a Nonlinear HIV/AIDS Dynamical System. Asian Journal of Applied Science and Engineering, 3, 96-113.

Haifeng Wang, MM, Hongsheng Lin, MM, and Gening Jiang, MD (2008).Pulmonary Resection in the Treatment ofMultidrug-Resistant Tuberculosis ARetrospective Study of 56 Cases. the Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China,2008,Ann Thorac Surg;86:1640 –5.

Hopewell, C. H. & Chaisson, R. E. (2000). Tuberculosis and human immunodeficiency virus infection. In: Tuberculosis. A Comprehensive International Approach, Reichmann, L. B. & Hershfield, E. S. (editors). New York & Base]: MarcelDekker, pp. 525-552.

Iseman MD; Iseman, Michael D. (1993). Treatment of multidrug-resistant tuberculosis. N Engl J Med 329 (11): 784–791.

Jacaban R F (1994). Multiple drug Resstant Tuberculosis; Clin. Infect. Dis. 19 1–10

Jeon DS, Shin DO, Park SK (2011). Treatment outcome and mortality among patients with multidrug-resistant tuberculosis in tuberculosis hospitals of the public sectors, 26(1):33-41. DOI: https://doi.org/10.3346/jkms.2011.26.1.33

Johnson J, Kagal A and Bharadwaj R (2003). Factors associated with drug resistance in pulmonary tuberculosis; Indian J. Chest Dis.Allied Sci. 45 105–109.

Juaeun N and Petms Nkamsse N. (2002). Impact of resistance to anti-tuberculosis drugs on treatment outcome using World Health Organization standard regimens. Transactions of the royal society of tropical medicine and hygiene, 96,429-433.

Kapp, C (2006). XDR tuberculosis spreads across South Africa. Lancet 369, 729.

Kassu D, Daniel A, Eshetu L, Mekdes G, Beniam F (2008).Drug susceptibility of Mycobacterium tuberculosis isolates from smear negative pulmonary tuberculosis patients, Addis Ababa, Ethiopia. Ethiop.J.Health Dev.22 (2):212-215.

Leimane V and Leimans J (2006). Integrated DOTS and DOTS plus programs. Euro surveillance, 11(3):29-33.

Lienhardt, C., Manneh, K., Bouchier, V., Lahai, G., Milligan, P. J. M. & McAdam, K. P. W. J. (1998). Factors determining the outcome of tieatrnent oi‘adult smear-positive tuberculosis cases in The Gambia. International Journal of Tuberculosis and Lung Disease, 2, 7 12-7 18.

Masanja, M., & Msuya, J. (2014). Social Changes Imposed by HIV and AIDS in Rural Areas: An Empirical Evidence of Sex Education in Maswa District, Tanzania. Asian Journal Of Applied Science And Engineering, 3(8), 49-62. doi:10.15590/ajase/2014/v3i8/54484 DOI: https://doi.org/10.15590/ajase/2014/v3i8/54484

Miguel G., Madariaga, MD, Umesh G. Lalloo, MBChB, MD, FCCP, Susan Swindells, MBBS (2008). Extensively Drug-resistant Tuberculosis. The American Journal of Medicine, 121, 835-844.

Mwinga A (2001). Drug resistant tuberculosis in Africa; Ann. N. Y. Acad. Sci. 953 106–112.

Neel R Gandhi, Paul Nunn, Keertan Dheda, H Simon Schaaf, Matteo Zignol, Dick van Soolingen, Paul Jensen, Jaime Bayona(2010).Multidrug-resistant and extensively drug-resistant tuberculosis a threat to global control of tuberculosis.Lancet, 375: 1830–43.

Pitchenik AE, Burr J, Laufer M (1990). Outbreaks of drug-resistant tuberculosis at AIDS centre. Lancet, 336: 440–441.

Prasad R (2005). MDR TB Current Status; Indian J. Tuberc. 52 121–131

Sharma SK and Mohan A (2003). Scientific basis of directly observed treatment, short course (DOTS); J. Indian Med. Assoc. 101 157–158,166.

Sharma SK and Mohan A (2004). Multidrug-resistant tuberculosis; Indian J. Med. Res. 120 354–376.

Sharma SK and Mohan A (2006). Multidrug-resistant tuberculosis: a menace that threatens to destabilize tuberculosis control; Chest 130 261–272 DOI: https://doi.org/10.1016/S0012-3692(15)50981-1

St.Peter’s TB Specialized Hospital (2007). Unpublished Human Resource Manual. 8:10-15.

Tadesse T, Hawaz Y and Zewdneh D. 2014. Patterns of Chest Radiographic Findings in Neonates with Respiratory Distress Admitted to the Neonatal Intensive Care Unit in Tikur Anbesa Specialized Hospital. Malaysian Journal of Medical and Biological Research, 1, 73-79.

Tupasi T.E, Quelapio M.I.D, Orillaza R.B, Alcantara C, Mira N.R.C, Abeleda M.R, Belen V.T, Arnisto N.M, Rivera A.B, Grimaldo E, Derilo J.O, Dimarucut W, Arabit M, Urboda D (2003). DOTS-Plus for multidrug-resistant tuberculosis in the Philippines: global assistance urgently needed, Tropical Disease Foundation 2003. DOI: https://doi.org/10.1016/S1472-9792(02)00072-0

Vaira L, Vija R, Timothy H , Evija Z, Vija Sk, Lorna E T, Kayla F L, Charles D (2005). Clinical outcome of individualized treatment of multidrug resistant tuberculosis in Latvia: a retrospective cohort study :Lancet 2005; 365: 318–26 DOI: https://doi.org/10.1016/S0140-6736(05)70196-3

WHO (2003). 7th annual report on global tuberculosis control. Geneva (2003).

World health organization (2010). Drug-resistant tuberculosis now at record levels.18, March.

World health organization (2010). Report on MDR-TB Nairobi Kenya 19, March.

www.cdc.gov/tb/publications/factsheets.

www.who.int/tb/challenges/mdr/

Zahan, N. (2013). HIV/AIDS Risk among the Children of Bangladesh. ABC Journal Of Advanced Research, 2(2), 30-43. Retrieved from http://journals.abc.us.org/index.php/abcjar/article/view/4.3%20Revised DOI: https://doi.org/10.18034/abcjar.v2i2.23

-- 0 --

Published

2015-06-30

Issue

Section

Peer-reviewed Article

How to Cite

Tulu, T. ., & Kahissay, M. H. . (2015). Assessment of Multidrug Resistance Tuberclosis Treatment Outcome in St. Petre’s Tuberclosis Specialized Hospital, Addis Ababa, Ethiopia. Malaysian Journal of Medical and Biological Research, 2(1), 7-18. https://doi.org/10.18034/mjmbr.v2i1.381