Bioinformatical Analysis of HGPRT Transferase from Different Malaria Parasite Plasmodium spp. Using Computational Tools
DOI:
https://doi.org/10.18034/mjmbr.v4i2.430Keywords:
HGPRT, Phosphoribosyl transferase, Plasmodium spp., Bioinformatics, Secondary structureAbstract
In this study, HGPRT transferases from different malaria parasite Plasmodium species was analyzed and presented in this communication. The composition of leucine, lysine and Isoleucine were the highest while lowest concentrations of tryptophan and glutamine residues were noticed when compared to other amino acids. pI value of P. reichenowi HGPRT was 7.59 while the lowest pI of 6.22 was shown by P. chabaudi HGPRT. The instability index of all the transferases is varied, but for all of them it was less than 40, which indicates that all of them are stable. The aliphatic index was found to span within a range of 83 to 97. Secondary structural analysis of the transferases showed the pre-dominance of random coils followed by extended strands for all the transferases except P. falciparum, P. Knowlesi and P. reichenowi HGPRT transferase. The significance of the above results is discussed in the light of existing literature.
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