Efficacy of Myrmecodia Platytyrae (MyP) Water Extract in Reducing Cholesterol Level in Hypercholesterolemia Induced Sprague Dawley Rat


  • M. K. Nik Hasan UITM
  • I. Abdul Wahab UITM
  • H. H. Mizaton UITM
  • M. A. Rasadah FRIM




Myrmecodia platytyrea, anti hypercholesterol, low density lipoprotein, high density lipoprotein


Myrmecodia plant or ant-nest plant is from Rubiaceae family. Rubiaceae are mainly tropical woody plants, consist mostly of trees and shrubs and can be found in temperate regions. Myrmecodia platytyrea (MyP) are believed to have medicinal value.  This study was designed in order to investigate the effect of MyP extract as anti hypercholesterolemic agent. The results showed that treatment of MyP can significantly reduce (p<0.05) low density lipoprotein (LDL) compared to negative control group. The extract was significantly increase (p<0.05) high density lipoprotein (HDL) concentration compared to negative control group. Besides that, MyP increased fecal cholesterol and fecal bile compared to normal control group. It was also found that lipid profile was significantly decreased (p<0.05) in MyP treatment group. All biochemistry data showed that MyP water extract was not toxic at all.


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Author Biographies

  • M. K. Nik Hasan, UITM

    Faculty of Pharmacy, Universiti Teknologi MARA (UITM), Bandar Puncak Alam, Selangor, 42300, MALAYSIA

  • I. Abdul Wahab, UITM

    Faculty of Pharmacy, Universiti Teknologi MARA (UITM), Bandar Puncak Alam, Selangor, 42300, MALAYSIA

  • H. H. Mizaton, UITM

    Faculty of Pharmacy, Universiti Teknologi MARA (UITM), Bandar Puncak Alam, Selangor, 42300, MALAYSIA

  • M. A. Rasadah, FRIM

    Natural Product Division, Forest Research Institute Malaysia, 52109 Kepong, Darul Ehsan, Selangor, MALAYSIA


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How to Cite

Hasan, M. K. N. ., Wahab, I. A. ., Mizaton, H. H. ., & Rasadah, M. A. . (2020). Efficacy of Myrmecodia Platytyrae (MyP) Water Extract in Reducing Cholesterol Level in Hypercholesterolemia Induced Sprague Dawley Rat. Malaysian Journal of Medical and Biological Research, 7(2), 69-80. https://doi.org/10.18034/mjmbr.v7i2.491

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