The Role of Punicalagin in Slowing Down the Decaying of Neurons

Authors

  • Dasika Sairam Vellore Institute of Technology

DOI:

https://doi.org/10.18034/mjmbr.v4i2.432

Keywords:

Punicalagin, microglial cells, Neurons

Abstract

Punicalagin is an active compound found in the Pomegranate rind. The hallmark of the compound is its antioxidant properties which is more than most other sources such as Red wine. The poly-phenol donates hydrogen to free radicals like peroxynitrites and prevents it from oxidizing and destroying microglial cells in the brain. The compound has high bio-availability and is has reduced neuronal inflammation as well. The compound is useful for treating Alzheimer’s, Parkinson’s, Huntington’s and many other Dementia’s. Apart from its antioxidant properties, the compound is an antidermatophyte and antimicrobial. Punicalagin has also shown ability in down regulating virulent Quorum sensing genes in Salmonella.

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Author Biography

  • Dasika Sairam, Vellore Institute of Technology

    Student Pursuing MSc in Biotechnology, Vellore Institute of Technology, Vellore, Tamil Nadu, INDIA

References

Adam A, Crespy V,Levrat-Verny MA,Leenhardt, Leuillet M,Demigne C, Remesy C; The bioavailability of Ferulic acid is governed primarily by the food matrix rather than its metabolism in intestine and liver in rats; Journal of Nutrition 2002 Jul; 132 Vol (Issue 7 ) 1962-68 pgs. DOI: https://doi.org/10.1093/jn/132.7.1962

Aviram M,Dornfeld L,Rosenblat M,Volkova N,Kaplan M,Coleman R,Hayek T, Presser D, Fuhrman Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice;American Journal of Clinical Nutrition; 2000 May;71(5) 1062-76pg DOI: https://doi.org/10.1093/ajcn/71.5.1062

Cerda B,Ceron JJ, Tomas-Barberan FA, Espin JC; Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic; Journal Agriculture and Food Chemistry; 2003 May 21;51(11) 3493-501pg DOI: https://doi.org/10.1021/jf020842c

Chih Hung Hsu, Ann Lii Cheng; Clinical studies with Curcumin Vol 595 2007, pp 471-480

Choi HR,Choi JS,Han YN,Bae SJ,Chung HY;Peroxynitrite scavenging activity of herb extracts; Phytotherapy Research; 2002 June 16(4) 364-7pg DOI: https://doi.org/10.1002/ptr.904

De Nigris F, Williams-Ignarro S, Sica V, Lerman LO, D’Armiento FP, Byrns RE, Casamassimi A, Carpentino D, Schiano C, Sumi D, Fiorito C, Ignarro LJ, Napoli C; Effects of a pomegranate fruit extract rich in Punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis; Cardiovascular Research 2007 Jan 15; 73 edition Issue 2; 414-423pgs DOI: https://doi.org/10.1016/j.cardiores.2006.08.021

Dills RL,Zhu X,Kalman DA;Measurement of urinary methoxyphenols and their use for biological monitoring of wood smoke exposure;Environment Research; 2001 Feb; 85(2); 145-58pgs. DOI: https://doi.org/10.1006/enrs.2000.4107

Foss SR,Nakamura CV,Ueda-Nakamura T, Cortez DA, Endo EH,Dias Filho BP; Antifungal activity of pomegranate peel extract and isolated compound punicalagin against dermatophytes; Annals of Clinical Microbiology and Anti microbials; 2014 Sept 5; 13 (1) DOI: https://doi.org/10.1186/s12941-014-0032-6

G Hartnoll, D Moore, D Douek; near fatal ingestion of oil of cloves; Archives of Disease in Childhood 1993, 69 edition, 392-393pg DOI: https://doi.org/10.1136/adc.69.3.392

Guanghui Li, Chunhong Yan, Yunfeng Xu, Yuqing Feng, Qian Wu, Xiaoying Lv, Baowei Yang, Xin Wang and Xiaodong Xia; Punicalagin Inhibits Salmonella Virulence Factors and Has Anti-Quorum-Sensing Potential; Applied and Environmental Microbiology; 80th Edition Issue 19; 6204-11pg DOI: https://doi.org/10.1128/AEM.01458-14

Hsiao C Wang, Julia L Brumaghim; Polyphenol Compounds as Antioxidants for Disease Prevention: Reactive Oxygen Species Scavenging, Enzyme Regulation, and Metal Chelation Mechanisms in E. coli and Human Cells; American Chemical Society; Vol 1083; Chapter 5; 99-175pg DOI: https://doi.org/10.1021/bk-2011-1083.ch005

Joerg Hucklenbroich, Rebecca Klein, Bernd Neumaier, Rudolf Graf, Gereon Rudolf Fink, Michael Schroeter and Maria Adele Rueger;Aromatic-turmerone induces neural stem cell proliferation in vitro and in vivo; Journal of Stem cell research and Therapy; Sept 2014; DOI: https://doi.org/10.1186/scrt500

Kikuzaki H,Hisamoto M,Hirose K, Akimaya K, Taniguch H; Antioxidant properties of Ferulic acid and its related compounds; Journal of Agriculture and Food Chemistry

MA Indap, S Radhika, Leena Motiwale, KVK Rao; Anticancer activity of phenolic antioxidants against breast cancer cells and a spontaneous mammary tumour; Indian Journal of Pharmaceutical Sciences 2006 Vol 68 Issue 4; 470-474pgs. DOI: https://doi.org/10.4103/0250-474X.27820

Olumayokun A. Olajide,Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji1 and Bernd L. Fiebich;Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia; Journal of Molecular Nutrition and Food Research; Volume 58 Issue 9; 1843-51pg;September 2014

Olumayokun A. Olajide,Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji1 and Bernd L. Fiebich;Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia;Journal of Molecular Nutrition and Food Research;Volume 58 Issue 9; 1843-51pg; September 2014

Olumayokun A. Olajide,Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji1 and Bernd L. Fiebich;Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia; Journal of Molecular Nutrition and Food Research; Volume 58 Issue 9; 1843-51pg; September 2014 DOI: https://doi.org/10.1002/mnfr.201400163

Saravana Kumar Jaganathan, Muthu Vignesh Vellayappan, Gayathri Narsimhan and Eko Supriyanto; Role of pomegranate and citrus fruit juices in colon cancer prevention; World Journal of Gastroenterology 2014 Apr 28; 20 (16): 4618-4625pgs. DOI: https://doi.org/10.3748/wjg.v20.i16.4618

Satomi H,Umemura K,Ueno A, Hatano T, Okuda T, Noro T; Carbonic anhydrase inhibitors from the pericarps of Punica granatum L; Biological and Pharmaceutical Bulletin; 1993 Aug 16 (8); 787-90pg DOI: https://doi.org/10.1248/bpb.16.787

Seiichiro Fujisawa, Toshiko Atsumi, Yoshinori Kadoma, Hiroshi Sakagami; Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity; Journal of Toxicology; Volume 177 Issue 1; August 2002, Pages 39-54 DOI: https://doi.org/10.1016/S0300-483X(02)00194-4

Shinichi TANIMOTO, Hitoshi TOMINAGA, Yoshiharu OKADA and MasatoNOMURA; Synthesis and Cosmetic Whitening Effect of Glycosides Derived from Several Phenylpropanoids; the Pharmaceutical Society of Japan YAKUGAKU ZASSHI 126 (3) 173 –177 (2006) DOI: https://doi.org/10.1248/yakushi.126.173

Sigrun Chrubasik-Hausmann, Christian Vlachojannis and Benno Zimmermann; Pomegranate Juice and Prostate Cancer: Importance of the Characterisation of the Active Principle; Journal of Phytotherapy Research Vol 28 Issue 11 1676-1678pg; Nov 2014 DOI: https://doi.org/10.1002/ptr.5181

Simone R Foss,Celso V Nakamura,Tania Ueda-Nakamura,Diogenes AG Cortez,Eliana H Endo and Benedito P Dias Filho; Antifungal activity of pomegranate peel extract and isolated compound Punicalagin against dermatophytes; Annals of Clinical Microbiology and Antimicrobials

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Published

2017-12-31

Issue

Section

Peer-reviewed Article

How to Cite

Sairam, D. . (2017). The Role of Punicalagin in Slowing Down the Decaying of Neurons. Malaysian Journal of Medical and Biological Research, 4(2), 97-100. https://doi.org/10.18034/mjmbr.v4i2.432